Research and Reviews
Looking for the basis for our treatment programs and results?
Here you go! Click a category to connect to a list of supporting research for our work.
Digestive System
Mental and Behavioral Health
Nervous System
Thyroid Dysfunction
Immune System
Musculoskeletal Conditions
Reproductive System
Supplements
Autoimmune Disease
Hormones
Chronic inflammation and other symptoms
Digestive System
Effect of lavender essential oil on LPS-stimulated inflammation
The gut-liver axis and the intersection with the microbiome
Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal
New insights into the pathogenesis of non-alcoholoic fatty liver disease: Gut-derived lipopolysaccharides and oxidative stress
Emerging roles for lymphatics in chronic liver disease
Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability
Plasma concentrations of zonulin are elevated in obese men with fatty liver disease
Exercise and gastrointestinal symptoms: running-induced changes in intestinal permeability and markers of gastrointestinal function in asymptomatic and symptomatic runners
Putting a stop to leaky gut
Vitamin A Inhibits the Actions of LPS on Intestinal Epithelial Barrie Function and Tight Junction Proteins
Vitamin D Deficiency Promotes Epithelial Barrier Dysfunction and Intestinal Inflammation
High-Saturated Fat Diet Increases Endotoxemia
Free fatty acids and insulin resistance
Interaction between free fatty acids and glucose metabolism
Moderate alcohol consumption is associated with small intestinal bacterial overgrowth, study finds
Systemic Viral Infections and Collateral Damage in the Liver
Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cells
The effects on stress on gastric ulceration, T3, T4, reverse T3 and cortisol in neonatal foals
Gastrointestinal lymphatics in health and disease
Mental and Behavioral Health
Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications
Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: a meta-analysis
The Role of Nutrition and the Gut-Brain Axis in Psychiatry: A Review of the Literature
Leaky gut biomarkers in depression and suicidal behavior
Effects of acute stress provocation on cortisol levels, zonulin and inflammatory markers in low- and high-stressed men
Alzheimer`s Disease Is Type 3 Diabetes – Evidence Reviewed
Increased Alzheimer`s risk during the menopause transition: A 3-year longitudinal brain imaging study
Low Testosterone Level and Risk of Alzheimers Disease in the Elderly Men: a Systematic Review and Meta-Analysis
The role of immune dysfunction in the pathophysiology of autism
Autoimmune and gastrointestinal dysfunctions: does a subset of children with autism reveal a broader connection?
Association of family history of autoimmune diseases and autism spectrum disorders.
Plasma cytokine levels in children with autistic disorder and unrelated siblings.
Behavioral correlates of maternal antibody status among children with autisum
Increased serum levels of anti-ganglioside M1 auto-antibodies in autistic children: relation to the disease severity
Detection of autoantibodies to neural cell of the cerebellus in the plasma of subjects with autism spectrum disorders
Altered gene expression and function of peripheral blood natural killer cells in children with autism
Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms
Autoantibodies to cerebellum in children with autism associate with behavior
Immunological effects of induced shame and guilt
Nervous System
Brain Drain
Olfaction in Parkinson’s disease and related disorders
Enteric nervous system manifestations of neurodegenerative disease
Biomarkers of intestinal barrier function in multiple sclerosis are associated with disease activity
Menigeal lymphatic network: The middleman of neuroinflammation
Meningeal lymphatics, immunity and neuroinflammation
Thyroid Dysfunction
Microbiota and Thyroid Interaction in Health and Disease
The effects of thyroid hormones on memory impairment and Alzheimers disease
Thyroid-stimulating hormone levels within the reference range are associated with serum lipid profiles independent of thyroid hormones
Thyroid peroxidase activity is inhibited by amino acids
Effects of thyroid hormones on stress ulcer formation
Atrophic body gastritis in patients with autoimmune thyroid disease: an underdiagnosed association
The Effect of the Thyroid Status on the Activation of Glycogen Synthase in Liver Cells
Immune System
Estrogen, Angiogenesis, Immunity and Cell Metabolism: Solving the Puzzle
Liver-spleen axis: Intersection between immunity, infections and metabolism
Immune Responses in the Liver
Liver immunology and its role in inflammation and homeostasis
Evidence of bacterial biofilms in nasal polyposis
Amino acids: metabolism, functions, and nutrition
Leukocyte-derived matrix metalloproteinase-9 in patients with coronary artery disease.
TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells
Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder?
The meningeal lymphatic system: a new player in neurophysiology
Musculoskeletal Conditions
Gut-disc axis: A cause of intervertebral disc degeneration and low back pain?
Reproductive System
Body Burden. The Pollution in newborns: A benchmark investigation of industrial chemicals, pollutants, and pesticides in human umbilical cord blood
Evaluation of serum zonulin for use as an early predictor for gestational diabetes
Ovarian adrenal interactions during the menopausal transition
Estrogens, Neuroinflammation, and neurodegeneration
Chronic depletion of gonadal testosterone leads to blood-brain barrier dysfunction and inflammation in male mice
Progesterone Within Ovulatory Menstrual Cycles Needed for Cardiovascular Protection: An Evidence-Based Hypothesis
Exercise Training in the Normal Female: Effects of low Energy Availability on Reproductive Function
The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder
Hormonal IUDS
Involvement of immune cells in pathogenesis of endometriosis
Bacterial contamination hypothesis: a new concept in endometriosis
Curcumin and endometriosis: Review on potential roles and molecular mechanisms
Irritable Bowel Syndrome-Like Disorders in Endometriosis: Prevalence of Nickle Sensitivity and Effects of a Low-Nickel Diet. An Open-Label Pilot Study
The Role of the Lymphatic System in Endometriosis: A Comprehensive Review of the Literature
Estrone (medication)
Inhibition of catechol-O-methyltransferase increase estrogen-DNA adduct formation
Estrogen-gut microbiome axis: Physiological and clinical implications
Supplements
Effectiveness of omega-3 ployunsaturated fatty acids against microbial pathogens
Mechanisms underlying the cardioprotective effect of L-cysteine
Cysteine metabolism and metal toxicity
A Review on Various Uses of N-Acetyl Cysteine
Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine
The chemistry and biological activities of N-acetylcysteine
N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action
N-Acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis
N-acetylcysteine augmentation therapy for moderate-to-severe obsessive-compulsive disorder: randomized, double-blind, placebo-controlled trial
N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study
The role of N-acetylcysteine in the management of COPD
Effect of High/Low Dose N-acetylcysteine on Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: meta-analysis of published double-blind, placebo-controlled clinical trials
The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review
High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis
N-Acetly cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial
The molecular basis for oxidative stress-induced insulin resistance
N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition
N-acetyl-L-cysteine exerts direct anti-aggregating effect on human platelets
Glutathione and immune function
N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules on A549 cells infected with highly pathogenic H5N1 influenza A virus
N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility
Adverse reactions associated with acetylcysteine
Getting a Knack for NAC
COVID-19 and therapy with essential oils having antiviral, anti-inflammatory, and immunomodulatory properties
Autoimmune Disease
Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms
Duodenal Cholescytokinin Triggers a Gut-Brain-Liver Axis To Regulate Glucose Production
Discrepancies Between Blood Glucose and Interstitial Glucose—Technological Artifacts or Physiology: Implications for Selection of the Appropriate Therapeutic Target
Hormones/Endocrine System
Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women
Chronic Inflammation and Other Symptoms
The Gut-Lung Axis in Systemic Inflammation. Role of Mesenteric Lymph as a Conduit