Research and Reviews 

Looking for the basis for our treatment programs and results?  
Here you go! Click a category to connect to a list of supporting research for our work.
Digestive System

Effect of lavender essential oil on LPS-stimulated inflammation

The gut-liver axis and the intersection with the microbiome

Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal

New insights into the pathogenesis of non-alcoholoic fatty liver disease: Gut-derived lipopolysaccharides and oxidative stress

Emerging roles for lymphatics in chronic liver disease

Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability

Plasma concentrations of zonulin are elevated in obese men with fatty liver disease

Exercise and gastrointestinal symptoms: running-induced changes in intestinal permeability and markers of gastrointestinal function in asymptomatic and symptomatic runners

Putting a stop to leaky gut

Vitamin A Inhibits the Actions of LPS on Intestinal Epithelial Barrie Function and Tight Junction Proteins

Vitamin D Deficiency Promotes Epithelial Barrier Dysfunction and Intestinal Inflammation 

High-Saturated Fat Diet Increases Endotoxemia

Free fatty acids and insulin resistance

Interaction between free fatty acids and glucose metabolism 

Moderate alcohol consumption is associated with small intestinal bacterial overgrowth, study finds 

Systemic Viral Infections and Collateral Damage in the Liver

Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cells

The effects on stress on gastric ulceration, T3, T4, reverse T3 and cortisol in neonatal foals 

Gastrointestinal lymphatics in health and disease
Mental and Behavioral Health

Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications

Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: a meta-analysis

The Role of Nutrition and the Gut-Brain Axis in Psychiatry: A Review of the Literature

Leaky gut biomarkers in depression and suicidal behavior

Effects of acute stress provocation on cortisol levels, zonulin and inflammatory markers in low- and high-stressed men

Alzheimer`s Disease Is Type 3 Diabetes – Evidence Reviewed 

Increased Alzheimer`s risk during the menopause transition: A 3-year longitudinal brain imaging study

Low Testosterone Level and Risk of Alzheimers Disease in the Elderly Men: a Systematic Review and Meta-Analysis 

The role of immune dysfunction in the pathophysiology of autism

Autoimmune and gastrointestinal dysfunctions: does a subset of children with autism reveal a broader connection?

Association of family history of autoimmune diseases and autism spectrum disorders.

Plasma cytokine levels in children with autistic disorder and unrelated siblings.

Behavioral correlates of maternal antibody status among children with autisum

Increased serum levels of anti-ganglioside M1 auto-antibodies in autistic children: relation to the disease severity

Detection of autoantibodies to neural cell of the cerebellus in the plasma of subjects with autism spectrum disorders

Altered gene expression and function of peripheral blood natural killer cells in children with autism

Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms

Autoantibodies to cerebellum in children with autism associate with behavior

Immunological effects of induced shame and guilt


Effectiveness of omega-3 ployunsaturated fatty acids against microbial pathogens

Mechanisms underlying the cardioprotective effect of L-cysteine

Cysteine metabolism and metal toxicity

A Review on Various Uses of N-Acetyl Cysteine

Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine

The chemistry and biological activities of N-acetylcysteine

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

N-Acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis

N-acetylcysteine augmentation therapy for moderate-to-severe obsessive-compulsive disorder: randomized, double-blind, placebo-controlled trial

N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study

The role of N-acetylcysteine in the management of COPD

Effect of High/Low Dose N-acetylcysteine on Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis

Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: meta-analysis of published double-blind, placebo-controlled clinical trials 

The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review

High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis

N-Acetly cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial 

The molecular basis for oxidative stress-induced insulin resistance

N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition 

N-acetyl-L-cysteine exerts direct anti-aggregating effect on human platelets

Glutathione and immune function

N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules on A549 cells infected with highly pathogenic H5N1 influenza A virus

N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility

Adverse reactions associated with acetylcysteine

Getting a Knack for NAC

COVID-19 and therapy with essential oils having antiviral, anti-inflammatory, and immunomodulatory properties